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Results from recent studies implicate multiple pathways for persister formation, including energy production, the stringent response, global regulators, the trans-translation pathway, proteasomal protein degradation, toxin-antitoxin modules, and transporter or efflux mechanisms. A combination of specifically persister-targeted approaches, such as… catching them when active and susceptible either by stimulating them to “wake up” mbt wingu or by intermittent drug dosing, mbt night the development of new drugs.
The use of appropriate drug mbt moja combinations, and combined mbt boots sale chemotherapy and immunotherapy, may be needed for more effective elimination of persisters and better treatment of TB. Variations in levels of persister formation and in host genetics can play a role in the outcome of clinical treatment, and thus, these may entail personalized treatment regimens.